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REFLECTIONS
Hypertension
Hypertension Global Newsletter #6 2024

This pooled analysis harmonised individual-level data from 112 cohort studies conducted in 34 countries and eight geographic
regions and included 1,518,028 participants (median age, 54.4 years). The Global Cardiovascular Risk Consortium aimed to assess
the effects of the five risk factors on the 10-year incidence of CVD and death from any cause.
Hypertension

Population-Attributable Fractions According to Different Regions for Five Modifiable Risk Factors Combined

While the prevalence of the five risk factors and the incidence of CVD and death from any cause varied across geographic regions
worldwide, women consistently displayed lower event rates compared to men, with global 10-year event rates in women of 4.0%
compared to 7.8% in men.

The Global Cardiovascular Risk Consortium found that 57.2% of incident CVD in women and 52.6% in men, and 22.2% of deaths in
women and 19.1% in men may be attributable to the five modifiable risk factors discussed earlier.

Global Population-Attributable Fractions for Five Modifiable Risk Factors Combined

Elevated SBP appeared to be the largest contributor to the population-attributable fraction of incident CVD events in all regions, with
the 10-year incidence of CVD associated with SBP as 29.3% (95% CI 25.4 to 33.2) among women and 21.6% (95% CI, 18.7 to 24.5)
among men. Addressing elevated SBP may offer the greatest potential for the prevention of CVD.

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